TALLERES

TALLER
MODELAJE MOLECULAR EN BIOLOGIA ESTRUCTURAL
(Auspiciado por el Centro de Estudios Avanzados del IVIC y el CONICIT)
Dr. Gerald Offer, Bristol University,
Dr. Raúl Padrón y Lic. Lorenzo Alamo, IVIC
Martes 2 de Marzo de 1999
DISPLAYING PROTEIN MOLECULES (MOLECULAR GRAPHICS):
a)Examples:
  • Structural Data-bases in Internet
  • Software for molecular modeling

  • b) Input ie pdb files, coordinate files and connectivity files.
    c) Representation of atoms as lines, balls and sticks, cpk, ribbon diagrams
    d) Using color, stereo, slab and rotation to pick out features of interest  eg
    particular residues, charge, subunits, ligands
    e) Comparing structures by superposition eg comparing acto-S1 pre and post powerstroke
    Resumen de la sesión

    Martes 9 de Marzo de 1999

    BUILDING MOLECULES AND ASSEMBLIES
    a) Building small organic molecules eg GTP
    b) Building polypeptide chains from residues with defined secondary structure.
    c) Putting together molecules from large fragments eg two-headed myosin
    molecules from proteolytically cleaved head and coiled coil
    d) Using symmetry (rotation and translation) to make assemblies such as F-actin and myosin filaments.
    Resumen de la sesión
    Martes 16 de Marzo de 1999
    MOLECULAR MECHANICS
    a)Energy minimisation
    b) Molecular dynamics
    c) Digital Scanning and Image processing of electron microgrphs
    Resumen de la sesión

    Martes 23 de Marzo de 1999

    FITTING OF ATOMIC MODELS TO 3D RECONSTRUCTIONS
    a) Helical three-dimensional reconstuction tecnique
  • SPIDER + WEB

  • b) displaying maps: slices, contour plots and surface views of reconstruction and model
    c) making density maps from models
    d) low-pass filtering
    e) correlation of model and reconstruction
    f) refining by downhill simplex and simulated annealing
    Resumen de la sesión

    Duración: 16 horas
    Creditos: 1
    Idioma: Inglés
    Lugar: Servicio de Procesamiento Digital de Imágenes (c. # 219) y Auditorium Karl Gaede, Departamento de Biología Estructural (DBE)

    Participantes Seleccionados


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